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\/>\n\u3010\u8ad6\u6587\u63b2\u8f09\u3011<br \/>\n\u63b2\u8f09\u8a8c\uff1aJournal of Proteome Research\uff08\u30a4\u30f3\u30d1\u30af\u30c8\u30d5\u30a1\u30af\u30bf\u30fc\uff1a3.6@2024\uff09<br \/>\n\u8ad6\u6587\u540d\uff1a<br \/>\nBrain metabolomics and bioinformatics analysis of a lipopolysaccharide\uff08LPS\uff09-induced acute inflammation model mouse reveal region-specific metabolic alterations and identify potential biomarkers of neuroinflammation<br \/>\n\uff08\u30ea\u30dd\u30dd\u30ea\u30b5\u30c3\u30ab\u30e9\u30a4\u30c9\uff08LPS\uff09\u8a98\u5c0e\u6025\u6027\u708e\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u8133\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u89e3\u6790\u53ca\u3073\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u89e3\u6790\u306b\u3088\u308a\u3001\u8133\u9818\u57df\u7279\u7570\u7684\u306a\u4ee3\u8b1d\u5909\u5316\u3068\u795e\u7d4c\u708e\u75c7\u306e\u6f5c\u5728\u7684\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u540c\u5b9a\u3057\u305f\uff09<br \/>\n\u8457\u8005\u3000\uff1a\u6749\u6d66\u4f38\u4e4b\u8f141\u3001\u8c37\u53e3\u8ce22\uff0a\u3001\u7b67\u667a\u8cb41\u3001\u5927\u8c37\u60a0\u65971\u3001\u6797\u7531\u7f8e3\u3001\u4e45\u6052\u4e00\u66434\u3001<br \/>\n\u3000\u3000\u3000\u3000\u6d45\u91ce\u53cb\u7f8e5\u3001\u6c5f\u53e3\u76db\u4e00\u90ce6\u3001\u4e95\u53e3\u4eae7\uff0a\u3001\u8ca1\u6d25\u68421\uff0a\u3000\uff0a\u5171\u540c\u8cac\u4efb\u8457\u8005<br \/>\n\u6240\u5c5e\u3000\uff1a1\u8fd1\u757f\u5927\u5b66\u751f\u7269\u7406\u5de5\u5b66\u90e8\u30012\u540d\u53e4\u5c4b\u5e02\u885b\u751f\u7814\u7a76\u6240\u30013\u540d\u53e4\u5c4b\u5927\u5b66\u3001<br \/>\n\u3000\u3000\u3000\u30004\u611b\u77e5\u770c\u8b66\u79d1\u5b66\u635c\u67fb\u7814\u7a76\u6240\u30015\u91d1\u57ce\u5b66\u9662\u5927\u5b66\u30016\u6771\u4eac\u5973\u5b50\u533b\u79d1\u5927\u5b66\u3001<br \/>\n\u3000\u3000\u3000\u30007\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6240<br \/>\n\u3010\u672c\u4ef6\u306e\u8a73\u7d30\u3011<br 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\u3092\u5b9f\u65bd\u3057\u305f\u7d50\u679c\u3001\u6d77\u99ac\u3001\u5c0f\u8133\u3001\u8996\u5e8a\u4e0b\u90e8\u3067\u306f\u6709\u610f\u5dee\u3092\u793a\u3059\u4ee3\u8b1d\u7269\u304c\u78ba\u8a8d\u3055\u308c\u306a\u304b\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u5927\u8133\u3067\u306f8\u7a2e\u985e\u306e\u4ee3\u8b1d\u7269\u306b\u3064\u3044\u3066\u6709\u610f\u5dee\uff08\u6709\u610f\u6c34\u6e96\uff1aFDR<\/p>\n<p>\n\t\u56f31\u3000\u5927\u8133\u3067\u6709\u610f\u5dee\u3092\u793a\u3057\u305f8\u7a2e\u985e\u306e\u4ee3\u8b1d\u7269\u306e\u7bb1\u3072\u3052\u56f3 \u8d64\u8272\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3001\u9752\u8272\u306f\u708e\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u7fa4\u3092\u793a\u3059\u3002\u4ee3\u8b1d\u7269\u306f\u4e0a\u6bb5\u5de6\u304b\u3089\u3001Malic acid\uff08\u30ea\u30f3\u30b4\u9178\uff09\u3001Aspartic acid\uff08\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\uff09\u3001Glyceraldehyde-3-phosphate\uff08\u30b0\u30ea\u30bb\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9-3-\u30ea\u30f3\u9178\uff09\u3001Tyrosine\uff08\u30c1\u30ed\u30b7\u30f3\uff09\u3001\u4e0b\u6bb5\u5de6\u304b\u3089\u3001N-acetylaspartate\uff08N-\u30a2\u30bb\u30c1\u30eb\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\uff09\u3001Urea\uff08\u5c3f\u7d20\uff09\u3001Asparagine\uff08\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\uff09\u3001Allose\/Glucose\/Galactose\/Mannose\uff08\u30a2\u30ed\u30fc\u30b9\uff0f\u30b0\u30eb\u30b3\u30fc\u30b9\uff0f\u30ac\u30e9\u30af\u30c8\u30fc\u30b9\uff0f\u30de\u30f3\u30ce\u30fc\u30b9\uff09\u3092\u793a\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u591a\u5909\u91cf\u89e3\u6790\u306e\u4e00\u3064\u3067\u3042\u308b\u6f5c\u5728\u69cb\u9020\u6295\u5f71\u5224\u5225\u5206\u6790\uff08PLS-DA\uff09\u203b5 \u3092\u5b9f\u65bd\u3057\u305f\u3068\u3053\u308d\u3001\u5927\u8133\u3067\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3068\u708e\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u7fa4\u306e\u30d7\u30ed\u30c3\u30c8\u304c\u826f\u597d\u306b\u5206\u96e2\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u5927\u8133\u306e\u4ee3\u8b1d\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u203b6 \u304c\u7570\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08\u56f32\uff09\u3002<\/p>\n<p>\n\t\u56f32\u3000\u6f5c\u5728\u69cb\u9020\u6295\u5f71\u5224\u5225\u5206\u6790\uff08PLS-DA\uff09\u306b\u3088\u308b\u30b9\u30b3\u30a2\u30d7\u30ed\u30c3\u30c8 Control\uff1a\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u3001Model\uff1a\u708e\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u7fa4\u3092\u793a\u3059\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u5927\u8133\u306b\u304a\u3044\u3066\u6709\u610f\u5dee\u3092\u793a\u3057\u305f\u4ee3\u8b1d\u7269\u3092\u7528\u3044\u3066\u6a5f\u68b0\u5b66\u7fd2\u306e\u4e00\u3064\u3067\u3042\u308b\u30e9\u30f3\u30c0\u30e0\u30d5\u30a9\u30ec\u30b9\u30c8\u203b7 \u306b\u3088\u308b\u5224\u5225\u30e2\u30c7\u30eb\u3092\u69cb\u7bc9\u3057\u3001\u4ea4\u5dee\u691c\u8a3c\u3092\u7528\u3044\u3066\u30e2\u30c7\u30eb\u306e\u59a5\u5f53\u6027\u3092\u78ba\u8a8d\u3057\u305f\u7d50\u679c\u3001\u3053\u308c\u3089\u306e8\u7a2e\u985e\u306e\u4ee3\u8b1d\u7269\u306f\u300c2\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u3092\u5206\u3051\u308b\u3053\u3068\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u6210\u5206\u300d\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u78ba\u306b\u793a\u3057\u307e\u3057\u305f\u3002<br \/>\n\u6709\u610f\u5dee\u3092\u793a\u3057\u305f\u4ee3\u8b1d\u7269\u306e\u3046\u3061\u3001N-\u30a2\u30bb\u30c1\u30eb\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u306f\u81e8\u5e8a\u7684\u306b\u795e\u7d4c\u969c\u5bb3\u30de\u30fc\u30ab\u30fc\uff08\u6307\u6a19\uff09\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u5316\u5408\u7269\u3067\u3042\u308a\u3001N-\u30a2\u30bb\u30c1\u30eb\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u306e\u4f4e\u4e0b\u306f\u795e\u7d4c\u969c\u5bb3\u3092\u793a\u3057\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u708e\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3067\u306fN-\u30a2\u30bb\u30c1\u30eb\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u5927\u8133\u306b\u304a\u3044\u3066\u795e\u7d4c\u969c\u5bb3\u304c\u751f\u3058\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u4ee3\u8b1d\u30d1\u30b9\u30a6\u30a7\u30a4\u89e3\u6790\u306e\u7d50\u679c\u3001\u708e\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3067\u306f\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u4ee3\u8b1d\u7d4c\u8def\u306a\u3089\u3073\u306b\u5c3f\u7d20\u56de\u8def\u306b\u7570\u5e38\u304c\u751f\u3058\u3001\u5927\u8133\u5185\u306b\u5c3f\u7d20\u304c\u84c4\u7a4d\u3059\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u306e\u7d50\u679c\u3001LPS\u6295\u4e0e\u306b\u3088\u308b\u5168\u8eab\u6027\u306e\u708e\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3067\u306f\u3001\u5927\u8133\u7279\u7570\u7684\u306b\u4ee3\u8b1d\u7570\u5e38\u304c\u751f\u3058\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<br \/>\n\u3010\u7528\u8a9e\u89e3\u8aac\u3011<br \/>\n\u203b1\u3000\u30ea\u30dd\u30dd\u30ea\u30b5\u30c3\u30ab\u30e9\u30a4\u30c9\uff08LPS\uff09\uff1a\u30b0\u30e9\u30e0\u9670\u6027\u83cc\u306e\u5916\u819c\u306b\u5b58\u5728\u3057\u3001\u5f37\u3044\u514d\u75ab\u523a\u6fc0\u6d3b\u6027\u3092\u6301\u3064\u3002\u5927\u91cf\u306b\u6295\u4e0e\u3059\u308b\u3068\u3001\u5f37\u529b\u306a\u708e\u75c7\u8a98\u767a\u7269\u8cea\u3068\u306a\u308a\u3001\u708e\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u4f5c\u6210\u306b\u6c4e\u7528\u3055\u308c\u308b\u3002<br \/>\n\u203b2\u3000IL-1\u03b2\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-1\u03b2\uff09\uff1a\u4e3b\u306b\u6d3b\u6027\u5316\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304b\u3089\u7523\u751f\u3055\u308c\u308b\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308a\u3001\u767a\u71b1\u3001\u795e\u7d4c\u708e\u75c7\u306a\u3069\u306b\u95a2\u4e0e\u3059\u308b\u3002<br \/>\n\u203b3\u3000PiTMaP\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\uff1a\u63a2\u91dd\u30a8\u30ec\u30af\u30c8\u30ed\u30b9\u30d7\u30ec\u30fc\u30a4\u30aa\u30f3\u5316\u30bf\u30f3\u30c7\u30e0\u8cea\u91cf\u5206\u6790\u3068\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u3092\u7d71\u5408\u3057\u305f\u89e3\u6790\u6cd5\u3067\u3042\u308a\u3001\u4ee4\u548c2\u5e74\uff082020\u5e74\uff09\u306b\u30a2\u30e1\u30ea\u30ab\u5316\u5b66\u4f1a\u306e\u56fd\u969b\u7684\u306a\u8ad6\u6587\u8a8cAnalytical Chemistry\u306b\u624b\u6cd5\u3092\u767a\u8868\u3057\u305f\u3002<br \/>\n\u203b4\u3000\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u89e3\u6790\uff1a\u7cd6\u985e\u3084\u30a2\u30df\u30ce\u9178\u3001\u6709\u6a5f\u9178\u3068\u3044\u3063\u305f\u4f4e\u5206\u5b50\uff08\u4ee3\u8b1d\u7269\uff09\u306e\u7db2\u7f85\u7684\u89e3\u6790\u6280\u8853\u306e\u3053\u3068\u3002<br \/>\n\u203b5\u3000\u6f5c\u5728\u69cb\u9020\u6295\u5f71\u5224\u5225\u5206\u6790\uff08PLS-DA\uff09\uff1a\u591a\u5909\u91cf\u89e3\u6790\u6cd5\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u9ad8\u6b21\u5143\u306e\u8aac\u660e\u5909\u6570\u3067\u8868\u3055\u308c\u305f\u30c7\u30fc\u30bf\u3092\u3001\u7fa4\u60c5\u5831\u3092\u4ed8\u4e0e\u3057\u3066\u4f4e\u6b21\u5143\u5316\u3092\u884c\u3046\u3002<br \/>\n\u203b6\u3000\u4ee3\u8b1d\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\uff1a\u500b\u3005\u306e\u4ee3\u8b1d\u7269\u306e\u5909\u5316\u304b\u3089\u4ee3\u8b1d\u5168\u4f53\u304c\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3057\u3066\u3044\u308b\u304b\u3092\u8868\u73fe\u3059\u308b\u3053\u3068\u3002\u4ee3\u8b1d\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306e\u5dee\u7570\u3092\u6bd4\u3079\u308b\u3053\u3068\u3067\u3001\u3069\u306e\u3088\u3046\u306a\u4ee3\u8b1d\u7269\u304c\u5909\u52d5\u3057\u3066\u3044\u308b\u304b\u3092\u53ef\u8996\u5316\u3067\u304d\u308b\u3002<br \/>\n\u203b7\u3000\u30e9\u30f3\u30c0\u30e0\u30d5\u30a9\u30ec\u30b9\u30c8\uff1a\u6a5f\u68b0\u5b66\u7fd2\u624b\u6cd5\u306e\u4e00\u3064\u3067\u3001\u591a\u6570\u306e\u6c7a\u5b9a\u6728\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u5b66\u7fd2\u3092\u884c\u3046\u30a2\u30f3\u30b5\u30f3\u30d6\u30eb\u6cd5\u3067\u3042\u308a\u3001\u8907\u96d1\u306a\u591a\u5909\u91cf\u30c7\u30fc\u30bf\u304b\u3089\u7279\u5fb4\u7684\u306a\u30d1\u30bf\u30fc\u30f3\u3092\u62bd\u51fa\u3057\u3066\u9ad8\u7cbe\u5ea6\u306a\u5206\u985e\u3092\u53ef\u80fd\u306b\u3059\u308b\u3002<br \/>\n\u3010\u5f15\u7528\u6587\u732e\u3011<br \/>\nKei Zaitsu*, et al., PiTMaP\uff1aA new analytical platform for high-throughput direct metabolome analysis by probe electrospray ionization\/tandem mass spectrometry using an R software-based data pipeline. Analytical Chemistry. 2020. 92\uff0812\uff09\uff1a8514-8522.<br \/>\n\u3010\u95a2\u9023\u30ea\u30f3\u30af\u3011<br \/>\n\u751f\u7269\u7406\u5de5\u5b66\u90e8\u3000\u751f\u547d\u60c5\u5831\u5de5\u5b66\u79d1\u3000\u6559\u6388\u3000\u8ca1\u6d25\u6842\uff08\u30b6\u30a4\u30c4\u30b1\u30a4\uff09<br \/>\n<a href=\"https:\/\/www.kindai.ac.jp\/meikan\/2758-zaitsu-kei.html\">https:\/\/www.kindai.ac.jp\/meikan\/2758-zaitsu-kei.html<\/a><br \/>\n\u751f\u7269\u7406\u5de5\u5b66\u90e8<br \/>\n<a href=\"https:\/\/www.kindai.ac.jp\/bost\/\">https:\/\/www.kindai.ac.jp\/bost\/<\/a>\n<\/p>\n<p><a href=\"https:\/\/www.atpress.ne.jp\/news\/560768\" title=\"\u8a73\u7d30\u306f\u3053\u3061\u3089\" target=\"_blank\" rel=\"nofollow\">\u8a73\u7d30\u306f\u3053\u3061\u3089<\/a><br \/>\n                                                    <br \/><a href=\"https:\/\/www.atpress.ne.jp\/\" title=\"\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u63d0\u4f9b\u5143\uff1a\uff20Press\" target=\"_blank\" rel=\"nofollow\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u63d0\u4f9b\u5143\uff1a\uff20Press<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u672c\u7814\u7a76\u306e\u6982\u8981\u56f3\uff08\u708e\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u8133\u3092\u89e3\u6790\u3057\u3001\u5927\u8133\u306e\u4ee3\u8b1d\u7570\u5e38\u3092\u78ba\u8a8d\uff09 \u8fd1\u757f\u5927\u5b66\u5927\u5b66\u9662\u751f\u7269\u7406\u5de5\u5b66\u7814\u7a76\u79d1\uff08\u548c\u6b4c\u5c71\u770c\u7d00\u306e\u5ddd\u5e02\uff09\u535a\u58eb\u524d\u671f\u8ab2\u7a0b2\u5e74\u3000\u6749\u6d66\u4f38\u4e4b\u8f14\u3001\u6559\u6388\u3000\u8ca1\u6d25\u6842\u3001\u540d\u53e4\u5c4b\u5e02\u885b\u751f\u7814\u7a76\u6240\uff08\u611b\u77e5\u770c\u540d\u53e4\u5c4b\u5e02\uff09\u7814\u7a76\u54e1\u3000\u8c37\u53e3\u8ce2\u3001\u6771\u4eac [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":13774,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":[],"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[489],"tags":[],"class_list":["post-13773","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rss"],"_links":{"self":[{"href":"https:\/\/town-t.com\/index.php?rest_route=\/wp\/v2\/posts\/13773","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/town-t.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/town-t.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/town-t.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/town-t.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13773"}],"version-history":[{"count":0,"href":"https:\/\/town-t.com\/index.php?rest_route=\/wp\/v2\/posts\/13773\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/town-t.com\/index.php?rest_route=\/wp\/v2\/media\/13774"}],"wp:attachment":[{"href":"https:\/\/town-t.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13773"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/town-t.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13773"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/town-t.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13773"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}